Except for the well known prognostic factors of cancer, the studies that perioperative transfusion f surgically resectable cancer could influence the survival of cancer patients were continued to be investigated.
The explanation of deleterious effects of transfusion has been supported by the results that the incidences of renal allograft rejection were decreased by pretransplantation transfusion, and transfusion resulted in changes of mononuclear cell
function
and inhibited natural killer cell activity. But definite proof of this adverse effect has not been settled.
We investigated whether perioperatve transfusion can diminish the survival rate of patients with colorectal cancer and transfusion itself can become prognostic factor by way of retrospective analysis of 104 surgically resected colorectal cancer
patients.
Five year survival rate of 46.2% in transfusion group(n=53) is significantly decreased compared with the rate of 73.9% in non-transfusion group(n=51)(P<0.05).
In subgroup analysis, there is no difference in survival rate by stage, the amount and component of blood transfusion. There are many other variables that can affect survival rate of cancer patients except for transfusion, multivariate Cox
regression
analysis was performed. The tumor differentiation is the greatest relative risk, but transfusion itself is not an independent prognostic value.
In conclusion, perioperative transfusion and the survival rate did not show direct relationship in these surgically resected colorectal colorectal cancer patients. Nevertheless the difference in survival rate between transfusion group and
non-transfusion group is significant, judicious use of blood products, use of frozen washed red blood cells that are totally lackin in white cells might be necessary. To confirm the direct causal relationship between perioperative transfusion and
the
survival in colorectal cancer, the larger prospective investigations are thought to e needed.
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